Endocrine Abstracts

Transfer of hematopoetic stem cells from mice transgenically overexpressing the islet autoantigen insulin could prevent type I diabetes in NOD mice. We tested if such an approach of tolerance induction could be employed by means of retroviral gene transfer of autoantigens into syngeneic hematopoetic stem cells (HSCs). We used glutamic acid decarboxylase 65 (GAD) as the autoantigen as T cell responses against GAD are more easily detected in NOD mice and as it has been previousl...